Hormone Replacement Therapy (HRT)

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Understanding Perimenopause and menopause Symptoms, Diagnosis, and Treatment Options

As we age, the body produces lower levels of key sex hormones like progesterone, estrogen, and testosterone. This decline can lead to significant changes in both the mind and body. Menopause, which typically occurs around age 51, is marked by 12 consecutive months without a period. However, there’s an important phase leading up to menopause known as perimenopause. During perimenopause, you may experience a range of unusual symptoms, and your perimenopause symptoms could begin as early as 10 years prior to your actual menopause.


The symptoms of perimenopause are often vague and can be difficult to pinpoint, making it hard to recognize when this phase is ending. For many women, perimenopause symptoms can be more intense than those of menopause itself. It’s essential to pay attention to these early signs and manage them effectively, so you can step off the hormonal roller coaster before menopause fully arrives.

Most women with perimenopause may experience the following symptoms, but not limited to: anxiety, irritability, skin and hair changes, difficulty sleeping, discomfort during sex, hot flushes, increases in facial hair, night sweats, weight gain, etc.


How can we diagnose perimenopause? 


Many labs may help to understand your perimenopause. Those labs include estradiol, progesterone, Testosterone, DHEA (If doing Saliva DHEA-S), progesterone to estradiol ratio, baseline CMP (rule out liver and renal issues), baseline CBC (will show anemia if menorrhagia is severe, normal period should not cause anemia), lipids (at least a baseline at age 25 and every 5 years if no other risk factors), baseline TSH, FT3, FT4 (thyroid imbalance can cause menstrual irregularity)


Treatment Options Explained


Oral Hormones:

Hormone replacements like estradiol and progesterone can effectively alleviate symptoms. Convenient daily capsules or tablets, often covered by insurance with copays. Slower absorption through the digestive system. Some herbal and natural supplements are available; though, it may take longer to see and feel relief. 


Topical Creams:

Topical creams with estradiol, progesterone, and testosterone deliver targeted, localized relief. Estradiol, progesterone, and testosterone creams provide targeted relief with faster skin absorption and fewer systemic effects.

Pellet Therapy:

Implantable hormone pellets offer consistent 3-6 month hormone delivery. Requires trained provider insertion; dose adjustments are challenging once implanted.



Age: Women who start hormone therapy at age 60 or older, or more than 10 years after the onset of menopause, have a higher risk for these conditions. However, starting hormone therapy before age 60 or within 10 years of menopause seems to offer benefits that may outweigh the risks.

Perimenopause vs. Menopause Treatment

Perimenopause symptoms often begin 10 years before actual menopause, affecting women as early as their 30s. Our approach addresses:

  • Irregular periods and heavy bleeding
  • Hot flashes and night sweats
  • Anxiety, irritability, and mood changes
  • Sleep disturbances and brain fog
  • Decreased libido and vaginal dryness

Risks Associated with HRT


In the largest clinical trial to date, hormone replacement therapy using an estrogen-progestin pill (Prempro) was linked to an increased risk of several serious conditions, including:

  • Heart disease
  • Stroke
  • Blood clots
  • Breast cancer

Managing HRT Risks & Benefits

While the 2002 WHI study raised concerns about HRT risks, current research shows benefits often outweigh risks when:

  • Treatment begins before age 60 or within 10 years of menopause
  • Bioidentical hormones are used at appropriate doses
  • Regular monitoring and adjustments occur
  • Individual risk factors are carefully assessed

Cost & Program Options

Oral hormones may have insurance coverage with copays. Creams and pellets are typically not covered but offer superior absorption and customization. We provide transparent pricing and receipts for potential insurance reimbursement.

Let’s talk!

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FAQs

Explore common questions for valuable insights.

We operate on a direct-pay model for personalized, unrestricted care. This eliminates prior authorizations and coverage limitations. We provide receipts for potential HSA/FSA reimbursement.

Yes. We require comprehensive hormone panels including estradiol, progesterone, testosterone, thyroid function, and metabolic markers to ensure safe, effective treatment.

Oral hormones are convenient but process through the liver. Creams absorb through skin for faster action. Pellets provide 3-6 months of steady hormone release but can’t be easily adjusted.

Many women notice improved sleep and mood within 2-4 weeks. Physical symptoms like hot flashes typically improve within 4-8 weeks of optimal dosing.